Chronic Myelogenous Leukemia (CML)

Chronic myelogenous leukemia (CML) is a type of blood cell cancers. The term "chronic (chronic)" in chronic leukemia myelogenosis derived from evidence progresses more slowly than acute leukemia types.

CML can also be called chronic myeloid leukemia and chronic granulocytic leukemia. Although it can occur at any age, CML is rare in children.


Chronic myelogenous leukemia have symptoms such as:

• Easy bleeding

• Weak

• Fever

• Frequent infections

• Loss of weight

• Loss of appetite

• Pain in the left rib

• Pale Skin

• Excessive Sweating while sleeping

Causes & Risk Factors


CML occurs when there is an error in the gene blood cells. It is unclear what caused the GCC process, but doctors have to know how the process of CML.

- Abnormalities of chromosome

Human cells normally have 23 chromosomes section. Chromosome affects DNA to control cells. In people with CML, chromosome shifted other parts of the chromosome. Exchange of chromosome 9 to chromosome 22, making an extra chromosome 22 and the short-term extra chromosome 9.

Short extra chromosome 22 called the Philadelphia chromosome, dimanakan by the name of the town where the chromosomes are found. Philadelphia chromosome present in 90 percent of people with CML.

- Abnormal chromosomes produce a new gene

Philadelphia chromosome to form new genes. Gene from chromosome 9 in combination with a gene from chromosome 22 to form a gene called BCR-ABL. BCR-ABL gene provides instructions to abnormal blood cells was to produce too much of a protein called tyrosine kinase. Tyrosine kinase encourage the cancer to develop.

- The new gene makes a lot of blood cell disorders

Your blood cells derived from bone marrow. When normal bone marrow function, bone marrow cells will produce young. These cells then mature and turn into different types of blood cells flowing in the body.

In CML process is not running as it should. Tyrosine kinase caused by BCR-ABL gene and makes too many white blood cells. Disorders of white blood cells is not making white blood cells die like normal cells. However, making a lot of white blood cells and interfere with healthy blood cells and damage the spinal cord.

Risk factors

Some factors that increase the risk of chronic myelogenous leukemia, among others:

• Old Aged

• Men

• Exposure to radiation, such as radiation therapy for certain types of cancer

Chromosome mutation that causes CML is not a condition that decreases from parents.